منابع مشابه
Astrocyte development and heterogeneity.
Astrocytes have many roles within the brain parenchyma, and a subpopulation restricted to germinal niches functions as neural stem cells (NSCs) that produce various types of neuronal progeny in relation to spatiotemporal factors. A growing body of evidence supports the concept of morphological and molecular differences between astrocytes in different brain regions, which might relate to their d...
متن کاملAstrocyte Heterogeneity or Homogeneity?
V. Parpura and P.G. Haydon (eds.), Astrocytes in (Patho)Physiology of the Nervous System, 1 DOI: 10.1007/978-0-387-79492-1_1, © Springer Science + Business Media, LLC 2009 The history of the morphology and electrophysiology of the neuroglia , which was the historical term used for what are now termed astroglia or astrocytes, is briefly reviewed. The interpretation of these data around 1970 was ...
متن کاملAstrocyte heterogeneity in the brain: from development to disease
In the last decades, astrocytes have risen from passive supporters of neuronal activity to central players in brain function and cognition. Likewise, the heterogeneity of astrocytes starts to become recognized in contrast to the homogeneous population previously predicted. In this review, we focused on astrocyte heterogeneity in terms of their morphological, protein expression and functional as...
متن کاملResolving Astrocyte Heterogeneity in the CNS
Astrocytes play essential roles in nearly all aspects of brain function from modulating synapses and neurovasculature to preserving appropriate extracellular solute concentrations. To meet the complex needs of the central nervous system (CNS), astrocytes possess highly specialized properties that are optimized for their surrounding neural circuitry. Precisely how these diverse astrocytes types ...
متن کاملClonal identity determines astrocyte cortical heterogeneity.
Astrocytes are the most numerous cell type in the brain, where they are known to play multiple important functions. While there is increasing evidence of their morphological, molecular, and functional heterogeneity, it is not clear whether their positional and morphological identities are specified during brain development. We address this problem with a novel strategy to analyze cell lineages ...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2014
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a020362